The Global Health Network Middle East and North Africa (TGHN MENA) was officially launched on 21 October 2024, representing a pivotal initiative to address the region’s distinct and complex public health challenges. Building on the comprehensive global framework of the central TGHN network, the regional TGHN MENA network was founded by region-based experts with support from the TGHN team. The network was established as a pioneering initiative to bring together 18 partners from 14 countries, representing various sectors such as academia, policymakers, and governmental and non-governmental organizations, to tackle pressing issues such as chronic diseases, mental health, and climate change impacts. High-level panel discussions were held to define the goals of TGHN MENA in building resilient public health systems. This perspective outlines the network’s vision for building resilient health systems through research prioritization and capacity strengthening, amidst growing uncertainties in the regional public health landscape. The MENA region has diverse and complex public health challenges related to health systems, emergencies, chronic disease, mental health disorders, and climate change, due to cultural, social, and geographic differences. The TGHN MENA network is a community of practice and can identify commonalities and priorities and find shareable solutions. Key strategies proposed include establishing an open-access, online platform to support knowledge exchange, implementing on-the-job training and capacity-strengthening initiatives, and emphasizing the use of artificial intelligence in public health research. This perspective outlines TGHN MENA’s inaugural one-year action plan, which emphasizes regular knowledge-sharing activities, capacity-building initiatives, and sustained partners’ commitment as foundational steps towards improved public health outcomes in the region.

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