Webinar: Pregnant Women & Vaccines Against Emerging Epidemic Threats: Ethics Guidance for Preparedness, Research, and Response, 5 March 2019
by The Editorial TeamOpen Public Consultation on “Strengthened cooperation against vaccine preventable diseases”
by The Editorial TeamThe European Commission is looking into ways to support EU member states to address re-emerging preventable diseases and to increase vaccine coverage in Europe. This policy discussion is set against the background of an increase of vaccination hesitancy in several countries, vaccines shortages and vaccines R&D challenges. As part of this process, The European Commission has launched a public consultation.
This is a great video of a talk given at the Oxford Martin School by Professor Kevin Marsh.
A Point-of-Care Assay to Detect Antimalarial Drugs from Finger Stick Blood Samples
by The Editorial TeamThis video seminar describes research to develop a low-cost, field-based test to detect several slow-clearing ACT drug compounds from unprocessed fingerstick blood samples
The European Mobile Laboratory, EMLab, was the first EBOV diagnostics unit deployed to the outbreak epicentre by WHO in March 2014.
Laboratory systems and diagnostic technologies are a critical pillar in the fight against malaria. The World Health Organization (WHO) recommends diagnostic testing for all people with suspected malaria before treatment is administered.
In the last decade, Ethiopia has achieved numerous public health successes, among them early attainment of health-related Millennium Development Goals, a strong tuberculosis (TB) management programme, and progress toward eradication of Guinea worm disease.
An interview with US Ambassador and GHSA Champion Dr. Bonnie Jenkins
Join us in Oxford on the 25th of April to mark World Malaria Day 2016 at a series of talks and a panel discussion. The speakers will present their latest projects and help us to understand the unique and interconnected findings of their research.
How a National Sample and Results Transport Network is Improving Patient Care in Uganda
by The Editorial TeamUganda has shown particular success in its National Sample and Results Transport Network (NSRTN).
Travel Medicine and Infectious Diseases have evolved rapidly in recent decades as outbreaks such as SARS, Avian Influenza, Ebola, MERS, Chikungunya, and Zika virus have demonstrated how quickly infections can cross international borders.
Great article from our colleagues at the African Society for Laboratory Medicine about Zika virus.
Video seminar by Chelsea McMullen, Operational Support Officer, International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), presented at the University of Oxford, 21st October 2015
This Week in Global Health or TWiGH presents Global Health Out Loud with Sulzhan Bali & Jessica Taaffe. This week they discuss Zika virus.
Call for Papers: Special issue on strengthening tuberculosis diagnostic networks in Africa - African Journal of Laboratory Medicine
Malaria remains a major global health threat. In the last fifteen years there has been remarkable progress in reducing cases and deaths due to malaria.
Deployed in April 2015, we have established proof-of-principle for real-time genomic surveillance by generating over 40 genome sequences in as little as 48 hours from obtaining a patient sample and feeding the information back to the Ebola central coordination team.
From our colleagues at the African Society for Laboratory Medicine (ASLM) - The Role of Public Health Institutes in Achieving Public Health Goals
Looking for a job in global health? A 4 part series that takes a look at what you need to do to get your career in global health off to a good start.
Damalie Nakanjako (MBChB, MMED, PhD) is an internist whose work focuses on optimizing HIV treatment outcomes and reducing HIV-associated morbidity and mortality in sub-Saharan Africa.
Twitter plays role in information distribution during emergencies, and it is widely used by public health organisations during public health crises.
Video of Professor Peter Horby, the University of Oxford, on how he and his team set up clinical trials in the heart of the Ebola outbreak.
East African Leaders Join Together to Develop Country-Specific Plans for Point-of-Care Testing.
Two great articles from the African Society for Laboratory Medicine looking at the increasing risk posed by antimicrobial resistance.
ASLM: Reconstructing Laboratory Systems: How to Rebuild in Ebola-Affected Countries
by The Editorial TeamNew articles from the African Society for Laboratory Medicine (ASLM).
Professor Lang talks about doing difficult trials in difficult places - including malaria and ebola trials.
Models for the discovery of new drugs against kinetoplastid diseases (Cutaneous leishmaniasis and chagas disease)
by The Editorial TeamCosts and effects of strategies to improve malaria diagnosis and treatment in Nigeria
by ACTConsortiumScientific title: A cost-effectiveness analysis of provider and community interventions to improve the treatment of uncomplicated malaria in Nigeria. Private-sector providers are a major source of malaria treatment in Nigeria, and many patients in Enugu state seek treatment at pharmacies and drug stores as well as public health centres.
Training manuals from REACT study in Cameroon. REACT Cameroon designed six training modules to support the introduction of malaria rapid diagnostic tests (RDTs). The manuals were used to train health workers at government and mission hospitals and health centres. The six modules are presented in two manuals
Use of rapid diagnostic tests to improve malaria treatment in the community in Uganda
by ACTConsortiumThis study evaluates whether the use of rapid diagnostic tests by community medicine distributors – with the aim to improve diagnosis and treatment of malaria in the community – is feasible, well accepted and cost-effective. This cluster randomized trial compares two approaches.
Improving Clinical Research Data: The Understanding and Implementation of Laboratory Quality Management System (LQMS)
by Augustine Onyeaghala. MSc, PhD, MSQA, PGDQA, FMLSCNThe Federation of Infectious Diseases Societies of Southern Africa (FIDSSA) Quarterly Journal
by Karla LamHealthcare associated infections (HAI) are of important concern in patient care. This talk discusses Visual Analytics techniques which have been developed to help detect, monitor, analyse and understand trends, clusters and outbreaks of HAI.
The SWAT and SWAR programme is identifying issues about the methods of trials and systematic reviews about which there is sufficient uncertainty to justify research to support well-informed decision making about future designs and choices.
Using parasite population genetics to understand transmission dynamics in NTDs
by The Editorial TeamSchistosomiasis, is a chronic, debilitating disease. Uganda began a National Control Programme in 2003 with annual MDA of praziquantel. MDA on this scale provides strong selective pressures on the parasite population with an associated risk of drug resistance developing.
Immunology and autoimmunity podcasts
by Nuffield Department of MedicineIn this video, Professor Theonest Mutabingwa discusses the two key challenges that face developing countries to progress their malaria research.
In this video of a seminar delivered at the University of Oxford in June 2014, Professor Nicholas White talks about the challenge of antimalarial resistance.
Anders Björkman is Professor of Infectious Disease at the Karolinska Institute. In this video, Anders talks about how the efficacy of antimalarials is a major obstacle in the path towards full malaria elimination.
Are you a research scientist working in Global Health? Or an institution looking for partners to run a clinical trial? Site Finder is for you.
Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance
by Mahima Swamy et alIn this seminar from January 2014, Dr Jane Crawley talks about clinical standardisation in PERCH (Pneumonia Etiology Research for Child Health), a large case-control study of the causes of and risk factors for severe pneumonia.
In this lecture Professor Adrian Hill talks about the latest advances in the development of vaccines for Malaria and Ebola.
Infectious diseases and Microbiology videos
by Nuffield Department of MedicineDr Nat Segaren - Medical Director of the Caris Foundation, presents on 'The Haiti National Early Infant Diagnosis of HIV Program'
Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain
by Vegard Eldholm et alFerritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE
by Scott Ayton et alNew Public Management (public sector reforms which draw on business ideology) are increasingly seen in African ministries of health. This talk concentrates on the effects of NPM reform on Ethiopian hospitals and how efforts to be 'more business-like' have many unintended consequences for hospitals and patients.
Professor Bongani M Mayosi from the Department of Medicine, Groote Schuur Hospital & University of Cape Town describes the transofmation of the science cohort in South Africa.
In this seminar Professor Kevin Marsh describes how knowledge of immunity to malaria in humans has developed over the past thirty years and what impact this has for future research.
Ebola Virus Entry: A Curious and Complex Series of Events
by Sven Moller-Tank, Wendy MauryEquator Network - Interview with the Equator Centre's Deputy Director
by Lab talk, Oxford MedSci NewsABRAID – The Atlas of Baseline Risk Assessment for Infectious Diseases - Call for feedback
by Dr Catherine MoyesABRAID, new website of infectious diseases risk maps
The Ebola Outbreak - Possible Implications that Media Reporting may Have -
by Cecaro M and Ramsamy YPioneering New Diagnostics: Addressing Challenges and Implications for Point-of-Care Testing in African Settings
by Laurel OldachAutophagy in malignant transformation and cancer progression
by Lorenzo Galluzzi et alReprogramming of cell fate: epigenetic memory and the erasure of memories past
by Buhe Nashun, Peter WS Hill, Petra HajkovaOpen Labware: 3-D Printing Your Own Lab Equipment
by Tom Baden et alNeutrophils: Between Host Defence, Immune Modulation, and Tissue Injury
by Philipp Kruger et alA Novel Host-Proteome Signature for Distinguishing between Acute Bacterial and Viral Infections
by Kfir Oved, et alCancer podcasts
by Karla LamA Stronger Post-Publication Culture Is Needed for Better Science
by Hilda BastianCXCL13 as a new biomarker of systemic lupus erythematosus and lupus nephritis – from bench to bedside?
by Karla LamUNICEF Cholera Toolkit
by UNICEFStructural Biology videos
by Oxford Nuffield Department of MedicineHIV/AIDS diagnostics technology landscape
by UnitaidHepatitis C diagnostics technology landscape
by UnitaidThe SLMTA programme: Transforming the laboratory landscape in developing countries
by Katy Yao, Talkmore Maruta, Elizabeth T. Luman, John N. NkengasongWHO Laboratory guidelines
by WHOEarly Virus-Host Interactions Dictate the Course of a Persistent Infection
by Brian M. Sullivan, John R. Teijaro, Juan Carlos de la Torre, Michael B. A. OldstoneThe Genetic and Mechanistic Basis for Variation in Gene Regulation
by Athma A. Pai, Jonathan K. Pritchard, Yoav GiladEffects of introducing Xpert MTB/RIF test on multi-drug resistant tuberculosis diagnosis in KwaZulu-Natal South Africa
by Nomonde R Dlamini-Mvelase, Lise Werner, Rogerio Phili, Lindiwe P Cele and Koleka P Mlisana"Harnessing the digital sharing revolution to improve research capacity in African laboratories”, Global Health Laboratories panel seminar at the ASLM2014
by Karla LamIn this article you can access and download the really interesting and useful Power Point presentations from the Global Health Laboratories panel seminar with regional experts held at the ASLM2014 last November.
Is Your Ethics Committee Efficient? Using “IRB Metrics” as a Self-Assessment Tool for Continuous Improvement at the Faculty of Tropical Medicine, Mahidol University, Thailand
by Pornpimon Adams et alHow to Make More Published Research True
by John P. A. IoannidisRapid and Inexpensive Detection of MDR Mycobacterium tuberculosis using a Resazurin Microtitreplate Assay in a High Burden Tuberculosis Reference Laboratory
by Prenika Jaglal, Melendhran Pillay, Koleka MlisanaProficiency Testing: Diagnosing Threats to Quality
by Laurel Oldach et alProfessor Peter Piot, LSHTM, talks about Ebola and implications for Africa and understanding future epidemics at the Martin School, University of Oxford, 16th October 2014.
Ebola PPE guidelines - urgent need to revise WHO and CDC guidelines. This video shows an excerpt from keynote address 'The fuss about face masks', Professor Raina MacIntyre from the School of Public Health and Community Medicine, UNSW Australia.
The Clinical and Economic Impact of Point-of-Care CD4 Testing in Mozambique and Other Resource-Limited Settings: A Cost-Effectiveness Analysis.
by Emily P. Hyle et al.Ten Simple Rules for Aspiring Scientists in a Low-Income Country
by Edgardo Moreno, José-María GutiérrezTen Simple Rules for Writing Research Papers and for Writing a Literature Review
by Weixiong Zhang and Marco PautassoTen Simple Rules for Approaching a New Job
by Philip E. BourneInfluence of weather conditions, drugs and comorbidities on serum Na and Cl in 13 000 hospital admissions: Evidence for a subpopulation susceptible for SIADH
by Christian Bucher et alAging and HIV/AIDS: pathogenetic role of therapeutic side effects
by Rebecca A Torres and William LewisCandida albicans Pathogenicity and Epithelial Immunity
by Naglik JR, Richardson JP, Moyes DLThe Ebola virus epidemic may well spread out of Africa. Dr Greg Martin takes a look at some of the variables that contribute to this risk and discusses some steps that should be taken.
An Integrated Lab-on-Chip for Rapid Identification and Simultaneous Differentiation of Tropical Pathogens
by Jeslin J. L. Tan, Monica Capozzoli, et alUnderstanding the principles of Good Clinical Laboratory Practices (GCLP) - Training presentations
by KEN AWUONDO, Karla LamDiabetes as a complication of adipose tissue dysfunction. Is there a role for potential new biomarkers?
by Katarzyna Bergmann and Grazyna SypniewskaOn the 8th of July 2014 The Global Health Network launched the Global Health Research Process Map, the first digital toolkit designed to enable researchers anywhere in the world to conduct rigorous global health research.
iPS cells: a game changer for future medicine
by Haruhisa Inoue, Naoki Nagata, Hiromi Kurokawa, Shinya YamanakaSeven principles for strengthening research capacity in low- and middle-income countries: simple ideas in a complex world
by ESSENCE on Health Research InitiativeThis good practice document of the ESSENCE on Health Research initiative is designed to provide broad guidance on how best to strengthen research capacity with the maximum possible benefit.
AuthorAid is a great online tool whose aim is to support developing country researchers in publishing their work.
A programme set up by WHO together with major publishers to provide free or very low cost online access to the major journals to local, not-for-profit institutions in developing countries.
Accurate reference values are essential for the correct interpretation of laboratory tests and clinical decision-making. Reference values should be established by testing a large number of healthy individuals. The results are then averaged and a range (plus or minus 2 standard deviations of the mean) of ‘normal’ values are established. The reference range of a test may be affected by the age and sex of the patient, and the variation is higher in some tests than in others. Because of this, reference values should be divided in groups according to age and gender, and ideally also according to ethnicity and geographical region.
Harmonization in Laboratory Medicine: the complete picture
by Mario PlebaniStrengthening national health laboratories in sub-Saharan Africa: a decade of remarkable progress
by G. A. Alemnji, C. Zeh, K. Yao and P. N. FonjungoHelpful, interactive eBook that aids those deciding how to further their career in research, or considernig whether to study as a post graduate.
The basic requirements for new sites wanting to take part in clinical research - What sites need to know!
by Caroline SibekoThe attached article, published in Emergency Medicine Volume 3 Issue 6, discusses the frequent use of antimicrobials in the critically ill which has led to the rise in multidrug resistant organisms.
Laboratory Challenges Conducting International Clinical Research in Resource-Limited Settings
by Fitzgibbon, Joseph E. PhD, Wallis, Carole L. PhDThis article explains how to write a cover letter for a research job, tailored for each job and to maximise your chances of securing an interview. Examples and templates are given.
This article describes how to seek research jobs which will suiit you, and how to work out from the job description the best ways to apply and secure an interview.
This article gives practical advice about how to create an excellent research CV, and has links to many templates and advice articles from around the world, as well as information about how to use the Professional Membership Scheme to create a free, formatted GCP-standard CV for you which can be used for site files and job applications.
In 2013, the WHO released a new set of guidelines on the prevention of mother to child transmission (PMTCT) of HIV/AIDS. The new guidelines suggests that all pregnant women who test positive for HIV should immediately begin a course of triple ARVs, regardless of CD4 cell levels.
Five keys to improving research costing in low- and middle-income countries
by ESSENCE on Health Research InitiativeESSENCE on Health Research have created a good practice document on research costing. It includes a review of the funding practices related to the definition and funding of direct and indirect costs.
This guide, developed by the WHO and released in December 2013, aims to facilitate implementation research in LMICs.
New publication on rifampicin Mono-Resistance in TB
by Yacoob Mahomed Coovadia, Sharana Mahomed, Melendhran Pillay, Lise Werner, Koleka MlisanaIdentification of Seroreactive Proteins of Leptospira interrogans Serovar Copenhageni Using a High-Density Protein Microarray Approach
by Carolina Lessa-Aquino, Camila Borges Rodrigues, Jozelyn Pablo, Rie Sasaki, Algis Jasinskas, Li Liang, Elsio A. Wunder Jr, Guilherme S. Ribeiro, Adam Vigil, Ricardo Galler, Douglas Molina, Xiaowu Liang, Mitermayer G. Reis, Albert I. Ko, Marco Alberto Medeiros, Philip L. FelgnerDiagnostic Accuracy of Loopamp Trypanosoma brucei Detection Kit for Diagnosis of Human African Trypanosomiasis in Clinical Samples
by Patrick Mitashi, Epco Hasker, Dieudonne Mumba Ngoyi, Pati Patient Pyana, Veerle Lejon, Wim Van der Veken, Pascal Lutumba, Philippe Buscher, Marleen Boelaert, Stijn Deborggraeve
Evaluation of a Typhoid/Paratyphoid Diagnostic Assay (TPTest) Detecting Anti-Salmonella IgA in Secretions of Peripheral Blood in Lymphocytes in Patients in Dhaka, Bangladesh
by Farhana Khanam, Alaullah Sheikh, Abu Sayeed, Saraur Bhuiyan, Feroza Kaneez Choudhury, Umme Salma, Shahnaz Pervin, Tania Sultana, Dilruba Ahmed, Doli Goswami, Lokman Hossain, KZ Mamun, Richell C Charles, W. Abdullah Brooks, Stephen B. Calderwood, Alejandro Cravioto, Edward T Ryan, Firdausi QadriProspective Evaluation of Three Rapid Diagnostic Tests for Diagnosis of Human Leptospirosis
by Marga GA Goris, Mariska MG Leeflang, Martin Loden, Jiri FP Wagenaar, Paul Klatser, Rudy A Hartseerl, Kimberly R BoerClinical Research Laboratories for Trials in Global Health in Central Africa
by ALI Innocent, akindeh, Prof Wilfred F. MbachamThe authors present the story of building a succesful research laboratory in Cameroon, including how they managed building up the infrastructure, equipment maintenance, staff training.
Development and Validation of a Novel Diagnostic Test for Human Brucellosis Using a Glyco-engineered Antigen Coupled to Magnetic Beads
by Andrés E. Ciocchini, Diego A. Rey Serantes, Luciano J. Melli, Jeremy A. Iwashkiw, Bettina Deodata, Jorge Wallach, Mario F. FEldman, Juan E. Ugalde, Diego J. ComerciSerious and Life-Threatening Pregnancy-Related Infections: Opportunities to Reduce the Global Burden
by Courtney A. GravettThis Policy Forum article aims to highlight opportunities for screening and appropriate treatment of life-threatening pregnancy-related interventions.
Streptococcal Pharyngitis - 2012 IDSA Guidelines
by Stanford T. Shulman, Alan L. Bisno, Herbert W. Clegg, Michael A. Gerber, Edward L. Kaplan, Grace Lee, Judith M. Martin, Chris Van BenedenPoint of Care Testing for Infectious Diseases: Diversity, Complexity and Barriers in Low- and Middle Income Countries
by Nitika Pant Pai, MD MPH PhD, Caroline Vadnais, Claudia Denkinger, Nora Engel, Madhu PaiThe Future of Diagnostic Microbiology – whole genome sequencing?
by Susanna DunachieVisceral leishmaniasis: what are the needs for diagnosis, treatment and control?
by François Chappuis, Shyam Sundar, Asrat Hailu, Hashim Ghalib, Suman Rijal, Rosanna W. PeelingDiagnosis of visceral leishmaniasis
by Pankaj Srivastava, Anand Dayama, Sanjana Mehrotra, Shyam SundarEnteric fever diagnostics reviews
by Paula Bianca BlomquistMicrofluid technologies
by Paula Bianca BlomquistMobile Phone Based Clinical Microscopy for Global Health Applications
by David N. Breslauer, Robi N. Maamari, Neil A. Switz, Wilbur A. Lam, Daniel A. FletcherWeb-Based Virtual Microscopy for Parasitology: A Novel Tool for Education and Quality Assurance
by Ewert Linder, Mikael Lundin, Cecilia Thors, Marianne Lebbad, Jadwiga Winiecka-Krusnell, Heikki Helin, Byron Leiva, Jorma Isola, Johan LundinAlternative methods of diagnosing drug resistance - What can they do for me?
by David AJ Moore, N Sarita ShahIdentification of Mimotopes with Diagnostic Potential for Trypanosoma brucei gambiense Varient Surfance Glycoproteins Using Human Antibody Fractions
by Liesbeth Van Nieuwenhove, Philippe Buscher, Fatima Balharbi, Michael Humbert, Tessa Dieltjens, Yves Guisez, Veerle LejonPoint-of-Care Tests to Strengthen Health Systems and Save Newborn Lives: The Case of Syphilis
by David Mabey, Kimberly Sollis, Helen Kelly, Adele Schwartz Benzaken, Edward Bitarakwate, John Changalucha, Xiang-Sheng Chen, Yue-Pin Ying, Patricia Garcia, Susan Strasser, Namwinga Chintu, Tikki Pang, Fern Terris-Prestholt, Sedona Sweeney, Rosanna PeelingDiagnostic Accuracy of Molecular Amplification Tests for Human African Trypanosomiasis—Systematic Review
by Claire M. Mugasa, Emily R. Adams, Kimberly R. Boer, Heleen C. Dyserinck, Philippe BüscherTowards Point-of-Care Diagnostic and Staging Tools for Human African Trypanosomiaisis
by Enock Matovu, Anne Juliet Kazibwe, Claire Mack Mugasa, Joseph Mathu Ndungu, Zablon Kithingi“Piggy-Backing” on Diagnostic Platforms Brings Hope to Neglected Diseases: The Case of Sleeping Sickness
by Joseph M Ndung'u, Sylvain Bieler, Giorgio RoscignoNucleic acid amplification testing for Neisseria gonorrhoeae: an ongoing challenge
by David M Whiley, John W Tapsall, Theo P SlootsJune’s article of the month features a paper from Infection and Drug Resistance called “High prevalence of extended-spectrum β-lactamase-producing pathogens: results of a surveillance study in two hospitals in Ujjain, India”.
Bug Challenge
by EditorsOur first "Bug Challenge" comes from Mahosot Hospital, Vientiane, Laos
May's article of the month features a supplement from Clinical Infectious Diseases on "Pneumonia Etiology Research for Clinical Health"
Laboratory data is crucial in ensuring subject safety and determining the effectiveness of an investigational medicinal product. Here are some issues to consider for clinical trial laboratories in resource-poor settings.