Webinar: Pregnant Women & Vaccines Against Emerging Epidemic Threats: Ethics Guidance for Preparedness, Research, and Response, 5 March 2019by The Editorial Team
The European Commission is looking into ways to support EU member states to address re-emerging preventable diseases and to increase vaccine coverage in Europe. This policy discussion is set against the background of an increase of vaccination hesitancy in several countries, vaccines shortages and vaccines R&D challenges. As part of this process, The European Commission has launched a public consultation.
Are you interested in improving global public health? Are willing to live in Zambia for a year? Do you have a Master’s degree? The Centre for Infectious Disease Research in Zambia (CIDRZ) is the largest independent non-governmental healthcare and research organisation in Zambia. They conduct locally-relevant, leading-edge healthcare research, strengthen primary health care systems in multiple focus areas, and run a state-of-the-art medical and research diagnostic laboratory.
Invitation to complete quick survey to improve Kaplan-Meier plots (KMunicate) ProblemThe standard way to present time-to-event data, such as survival, is with Kaplan-Meier plots. These are formatted by journals and reported in a number of ways, but we find they commonly lack some key information. The key problems are:
- Expressing how many people are contributing data at any point in the graph, including the pattern of censoring
- Expressing that the uncertainty of the estimate increases over time
This is a great video of a talk given at the Oxford Martin School by Professor Kevin Marsh.
AREF is calling for researcher applications to participate in its 2nd Essential Grant Writing Skills Workshop, to be held in Dakar, Senegal, in May 2017.
This video seminar describes research to develop a low-cost, field-based test to detect several slow-clearing ACT drug compounds from unprocessed fingerstick blood samples
The European Mobile Laboratory, EMLab, was the first EBOV diagnostics unit deployed to the outbreak epicentre by WHO in March 2014.
Laboratory systems and diagnostic technologies are a critical pillar in the fight against malaria. The World Health Organization (WHO) recommends diagnostic testing for all people with suspected malaria before treatment is administered.
In the last decade, Ethiopia has achieved numerous public health successes, among them early attainment of health-related Millennium Development Goals, a strong tuberculosis (TB) management programme, and progress toward eradication of Guinea worm disease.
An interview with US Ambassador and GHSA Champion Dr. Bonnie Jenkins
Join us in Oxford on the 25th of April to mark World Malaria Day 2016 at a series of talks and a panel discussion. The speakers will present their latest projects and help us to understand the unique and interconnected findings of their research.
Uganda has shown particular success in its National Sample and Results Transport Network (NSRTN).
Travel Medicine and Infectious Diseases have evolved rapidly in recent decades as outbreaks such as SARS, Avian Influenza, Ebola, MERS, Chikungunya, and Zika virus have demonstrated how quickly infections can cross international borders.
Great article from our colleagues at the African Society for Laboratory Medicine about Zika virus.
Video seminar by Chelsea McMullen, Operational Support Officer, International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), presented at the University of Oxford, 21st October 2015
This Week in Global Health or TWiGH presents Global Health Out Loud with Sulzhan Bali & Jessica Taaffe. This week they discuss Zika virus.
Call for Papers: Special issue on strengthening tuberculosis diagnostic networks in Africa - African Journal of Laboratory Medicine
Malaria remains a major global health threat. In the last fifteen years there has been remarkable progress in reducing cases and deaths due to malaria.
Deployed in April 2015, we have established proof-of-principle for real-time genomic surveillance by generating over 40 genome sequences in as little as 48 hours from obtaining a patient sample and feeding the information back to the Ebola central coordination team.
From our colleagues at the African Society for Laboratory Medicine (ASLM) - The Role of Public Health Institutes in Achieving Public Health Goals
Looking for a job in global health? A 4 part series that takes a look at what you need to do to get your career in global health off to a good start.
Damalie Nakanjako (MBChB, MMED, PhD) is an internist whose work focuses on optimizing HIV treatment outcomes and reducing HIV-associated morbidity and mortality in sub-Saharan Africa.
Twitter plays role in information distribution during emergencies, and it is widely used by public health organisations during public health crises.
Video of Professor Peter Horby, the University of Oxford, on how he and his team set up clinical trials in the heart of the Ebola outbreak.
East African Leaders Join Together to Develop Country-Specific Plans for Point-of-Care Testing.
Two great articles from the African Society for Laboratory Medicine looking at the increasing risk posed by antimicrobial resistance.
New articles from the African Society for Laboratory Medicine (ASLM).
Professor Lang talks about doing difficult trials in difficult places - including malaria and ebola trials.
Models for the discovery of new drugs against kinetoplastid diseases (Cutaneous leishmaniasis and chagas disease)by The Editorial Team
Scientific title: A cost-effectiveness analysis of provider and community interventions to improve the treatment of uncomplicated malaria in Nigeria. Private-sector providers are a major source of malaria treatment in Nigeria, and many patients in Enugu state seek treatment at pharmacies and drug stores as well as public health centres.
Training manuals from REACT study in Cameroon. REACT Cameroon designed six training modules to support the introduction of malaria rapid diagnostic tests (RDTs). The manuals were used to train health workers at government and mission hospitals and health centres. The six modules are presented in two manuals
This study evaluates whether the use of rapid diagnostic tests by community medicine distributors – with the aim to improve diagnosis and treatment of malaria in the community – is feasible, well accepted and cost-effective. This cluster randomized trial compares two approaches.
Improving Clinical Research Data: The Understanding and Implementation of Laboratory Quality Management System (LQMS)by Augustine Onyeaghala. MSc, PhD, MSQA, PGDQA, FMLSCN
Healthcare associated infections (HAI) are of important concern in patient care. This talk discusses Visual Analytics techniques which have been developed to help detect, monitor, analyse and understand trends, clusters and outbreaks of HAI.
The SWAT and SWAR programme is identifying issues about the methods of trials and systematic reviews about which there is sufficient uncertainty to justify research to support well-informed decision making about future designs and choices.
Schistosomiasis, is a chronic, debilitating disease. Uganda began a National Control Programme in 2003 with annual MDA of praziquantel. MDA on this scale provides strong selective pressures on the parasite population with an associated risk of drug resistance developing.
In this video, Professor Theonest Mutabingwa discusses the two key challenges that face developing countries to progress their malaria research.
In this video of a seminar delivered at the University of Oxford in June 2014, Professor Nicholas White talks about the challenge of antimalarial resistance.
Anders Björkman is Professor of Infectious Disease at the Karolinska Institute. In this video, Anders talks about how the efficacy of antimalarials is a major obstacle in the path towards full malaria elimination.
Are you a research scientist working in Global Health? Or an institution looking for partners to run a clinical trial? Site Finder is for you.
In this seminar from January 2014, Dr Jane Crawley talks about clinical standardisation in PERCH (Pneumonia Etiology Research for Child Health), a large case-control study of the causes of and risk factors for severe pneumonia.
In this lecture Professor Adrian Hill talks about the latest advances in the development of vaccines for Malaria and Ebola.
Dr Nat Segaren - Medical Director of the Caris Foundation, presents on 'The Haiti National Early Infant Diagnosis of HIV Program'
Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOEby Scott Ayton et al
New Public Management (public sector reforms which draw on business ideology) are increasingly seen in African ministries of health. This talk concentrates on the effects of NPM reform on Ethiopian hospitals and how efforts to be 'more business-like' have many unintended consequences for hospitals and patients.
Professor Bongani M Mayosi from the Department of Medicine, Groote Schuur Hospital & University of Cape Town describes the transofmation of the science cohort in South Africa.
In this seminar Professor Kevin Marsh describes how knowledge of immunity to malaria in humans has developed over the past thirty years and what impact this has for future research.
ABRAID, new website of infectious diseases risk maps
Pioneering New Diagnostics: Addressing Challenges and Implications for Point-of-Care Testing in African Settingsby Laurel Oldach
CXCL13 as a new biomarker of systemic lupus erythematosus and lupus nephritis – from bench to bedside?by Karla Lam
Effects of introducing Xpert MTB/RIF test on multi-drug resistant tuberculosis diagnosis in KwaZulu-Natal South Africaby Nomonde R Dlamini-Mvelase, Lise Werner, Rogerio Phili, Lindiwe P Cele and Koleka P Mlisana
"Harnessing the digital sharing revolution to improve research capacity in African laboratories”, Global Health Laboratories panel seminar at the ASLM2014by Karla Lam
In this article you can access and download the really interesting and useful Power Point presentations from the Global Health Laboratories panel seminar with regional experts held at the ASLM2014 last November.
Is Your Ethics Committee Efficient? Using “IRB Metrics” as a Self-Assessment Tool for Continuous Improvement at the Faculty of Tropical Medicine, Mahidol University, Thailandby Pornpimon Adams et al
Rapid and Inexpensive Detection of MDR Mycobacterium tuberculosis using a Resazurin Microtitreplate Assay in a High Burden Tuberculosis Reference Laboratoryby Prenika Jaglal, Melendhran Pillay, Koleka Mlisana
Professor Peter Piot, LSHTM, talks about Ebola and implications for Africa and understanding future epidemics at the Martin School, University of Oxford, 16th October 2014.
Ebola PPE guidelines - urgent need to revise WHO and CDC guidelines. This video shows an excerpt from keynote address 'The fuss about face masks', Professor Raina MacIntyre from the School of Public Health and Community Medicine, UNSW Australia.
The Clinical and Economic Impact of Point-of-Care CD4 Testing in Mozambique and Other Resource-Limited Settings: A Cost-Effectiveness Analysis.by Emily P. Hyle et al.
Influence of weather conditions, drugs and comorbidities on serum Na and Cl in 13 000 hospital admissions: Evidence for a subpopulation susceptible for SIADHby Christian Bucher et al
The Ebola virus epidemic may well spread out of Africa. Dr Greg Martin takes a look at some of the variables that contribute to this risk and discusses some steps that should be taken.
An Integrated Lab-on-Chip for Rapid Identification and Simultaneous Differentiation of Tropical Pathogensby Jeslin J. L. Tan, Monica Capozzoli, et al
Diabetes as a complication of adipose tissue dysfunction. Is there a role for potential new biomarkers?by Katarzyna Bergmann and Grazyna Sypniewska
On the 8th of July 2014 The Global Health Network launched the Global Health Research Process Map, the first digital toolkit designed to enable researchers anywhere in the world to conduct rigorous global health research.
Seven principles for strengthening research capacity in low- and middle-income countries: simple ideas in a complex worldby ESSENCE on Health Research Initiative
This good practice document of the ESSENCE on Health Research initiative is designed to provide broad guidance on how best to strengthen research capacity with the maximum possible benefit.
AuthorAid is a great online tool whose aim is to support developing country researchers in publishing their work.
A programme set up by WHO together with major publishers to provide free or very low cost online access to the major journals to local, not-for-profit institutions in developing countries.
Accurate reference values are essential for the correct interpretation of laboratory tests and clinical decision-making. Reference values should be established by testing a large number of healthy individuals. The results are then averaged and a range (plus or minus 2 standard deviations of the mean) of ‘normal’ values are established. The reference range of a test may be affected by the age and sex of the patient, and the variation is higher in some tests than in others. Because of this, reference values should be divided in groups according to age and gender, and ideally also according to ethnicity and geographical region.
Helpful, interactive eBook that aids those deciding how to further their career in research, or considernig whether to study as a post graduate.
The basic requirements for new sites wanting to take part in clinical research - What sites need to know!by Caroline Sibeko
The attached article, published in Emergency Medicine Volume 3 Issue 6, discusses the frequent use of antimicrobials in the critically ill which has led to the rise in multidrug resistant organisms.
This article explains how to write a cover letter for a research job, tailored for each job and to maximise your chances of securing an interview. Examples and templates are given.
This article describes how to seek research jobs which will suiit you, and how to work out from the job description the best ways to apply and secure an interview.
This article gives practical advice about how to create an excellent research CV, and has links to many templates and advice articles from around the world, as well as information about how to use the Professional Membership Scheme to create a free, formatted GCP-standard CV for you which can be used for site files and job applications.
In 2013, the WHO released a new set of guidelines on the prevention of mother to child transmission (PMTCT) of HIV/AIDS. The new guidelines suggests that all pregnant women who test positive for HIV should immediately begin a course of triple ARVs, regardless of CD4 cell levels.
ESSENCE on Health Research have created a good practice document on research costing. It includes a review of the funding practices related to the definition and funding of direct and indirect costs.
This guide, developed by the WHO and released in December 2013, aims to facilitate implementation research in LMICs.
Identification of Seroreactive Proteins of Leptospira interrogans Serovar Copenhageni Using a High-Density Protein Microarray Approachby Carolina Lessa-Aquino, Camila Borges Rodrigues, Jozelyn Pablo, Rie Sasaki, Algis Jasinskas, Li Liang, Elsio A. Wunder Jr, Guilherme S. Ribeiro, Adam Vigil, Ricardo Galler, Douglas Molina, Xiaowu Liang, Mitermayer G. Reis, Albert I. Ko, Marco Alberto Medeiros, Philip L. Felgner
Diagnostic Accuracy of Loopamp Trypanosoma brucei Detection Kit for Diagnosis of Human African Trypanosomiasis in Clinical Samplesby Patrick Mitashi, Epco Hasker, Dieudonne Mumba Ngoyi, Pati Patient Pyana, Veerle Lejon, Wim Van der Veken, Pascal Lutumba, Philippe Buscher, Marleen Boelaert, Stijn Deborggraeve
Evaluation of a Typhoid/Paratyphoid Diagnostic Assay (TPTest) Detecting Anti-Salmonella IgA in Secretions of Peripheral Blood in Lymphocytes in Patients in Dhaka, Bangladeshby Farhana Khanam, Alaullah Sheikh, Abu Sayeed, Saraur Bhuiyan, Feroza Kaneez Choudhury, Umme Salma, Shahnaz Pervin, Tania Sultana, Dilruba Ahmed, Doli Goswami, Lokman Hossain, KZ Mamun, Richell C Charles, W. Abdullah Brooks, Stephen B. Calderwood, Alejandro Cravioto, Edward T Ryan, Firdausi Qadri
The authors present the story of building a succesful research laboratory in Cameroon, including how they managed building up the infrastructure, equipment maintenance, staff training.
Development and Validation of a Novel Diagnostic Test for Human Brucellosis Using a Glyco-engineered Antigen Coupled to Magnetic Beadsby Andrés E. Ciocchini, Diego A. Rey Serantes, Luciano J. Melli, Jeremy A. Iwashkiw, Bettina Deodata, Jorge Wallach, Mario F. FEldman, Juan E. Ugalde, Diego J. Comerci
Serious and Life-Threatening Pregnancy-Related Infections: Opportunities to Reduce the Global Burdenby Courtney A. Gravett
This Policy Forum article aims to highlight opportunities for screening and appropriate treatment of life-threatening pregnancy-related interventions.
Point of Care Testing for Infectious Diseases: Diversity, Complexity and Barriers in Low- and Middle Income Countriesby Nitika Pant Pai, MD MPH PhD, Caroline Vadnais, Claudia Denkinger, Nora Engel, Madhu Pai
Identification of Mimotopes with Diagnostic Potential for Trypanosoma brucei gambiense Varient Surfance Glycoproteins Using Human Antibody Fractionsby Liesbeth Van Nieuwenhove, Philippe Buscher, Fatima Balharbi, Michael Humbert, Tessa Dieltjens, Yves Guisez, Veerle Lejon
Diagnostic Accuracy of Molecular Amplification Tests for Human African Trypanosomiasis—Systematic Reviewby Claire M. Mugasa, Emily R. Adams, Kimberly R. Boer, Heleen C. Dyserinck, Philippe Büscher
“Piggy-Backing” on Diagnostic Platforms Brings Hope to Neglected Diseases: The Case of Sleeping Sicknessby Joseph M Ndung'u, Sylvain Bieler, Giorgio Roscigno
Indian Bacterial Surveillance Study Shows High Number of Resistant Bacteria - Article of the Month, June 2012by Editors
June’s article of the month features a paper from Infection and Drug Resistance called “High prevalence of extended-spectrum β-lactamase-producing pathogens: results of a surveillance study in two hospitals in Ujjain, India”.
Our first "Bug Challenge" comes from Mahosot Hospital, Vientiane, Laos
May's article of the month features a supplement from Clinical Infectious Diseases on "Pneumonia Etiology Research for Clinical Health"
Laboratory data is crucial in ensuring subject safety and determining the effectiveness of an investigational medicinal product. Here are some issues to consider for clinical trial laboratories in resource-poor settings.